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Amphetamine

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Km (μM) Cell System Reference
SLC22A2 OCT2 0.83 HEK293-OCT2 Wagner, 2017
SLC47A1 MATE1 14 HEK293-MATE1 Wagner, 2017
SLC47A2 MATE2K 16 HEK293-MATE2K Wagner, 2017
SLC22A2 OCT2 534 HEK293-OCT2 Wagner, 2017

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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
SLC22A5 OCTN2 Amphetamine 6000 L-carnitine BeWo cells expressing OCTN2 Rytting, 2005
SLC22A1 OCT1 Amphetamine 97 Metformin HEK293-OCT1 Wagner, 2017
SLC22A2 OCT2 Amphetamine 20.3 Metformin HEK293-OCT2 Wagner, 2017
SLC47A1 MATE1 Amphetamine 94 Metformin HEK293-MATE1 Wagner, 2017
SLC47A2 MATE2K Amphetamine 158 Metformin HEK293-MATE2K Wagner, 2017

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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