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Amoxicillin

In Vitro Substrates

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Km (μM)	Cell System	Reference
SLC15A2	PEPT2	1040	MDCK-PEPT2	Li, 2006
SLC15A1	PEPT1	ND	MDCK-PEPT1	Li, 2006
SLC22A8	OAT3	161.4	HEK293-OAT3	Parvez, 2018

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Inhibitor	IC50 (μM)	Ki (μM)	Substrate used	Cell System	Reference
ABCC2	MRP2, cMOAT	Amoxicillin	>133		Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
ABCC3	MRP3	Amoxicillin	>133		Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
ABCC4	MRP4	Amoxicillin	>133		Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
SLCO1B1	OATP1B1, OATP-C, OATP2, LST-1	Amoxicillin	36.2		Estrone sulfate	HEK-OATP1B1	Parvez, 2016
SLC15A2	PEPT2	Amoxicillin		733	Glycylsarcosine	MDCK-PEPT2	Li, 2006
ABCB11	BSEP	Amoxicillin	>133		Taurocholate	Sf9 cell membrane vesicles	Morgan, 2013

No drug-drug interaction information.