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Amiloride

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Km (μM) Cell System Reference
SLC22A2 OCT2 95 HEK293-OCT2 Biermann, 2006

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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
SLC47A1 MATE1 Amiloride 2.4 1-methyl-4-phenylpyridinium (MPP+) CHO-MATE1 Astorga, 2012
SLC47A2 MATE2K Amiloride 3.06 1-methyl-4-phenylpyridinium (MPP+) CHO-MATE2K Astorga, 2012
SLC22A1 OCT1 Amiloride 57 4-(4-dimethylamino)styryl-N-methylpyridinium (ASP+) HEK293-OCT1 Ahlin, 2008
SLC22A3 OCT3 Amiloride 14.5 4-(4-dimethylamino)styryl-N-methylpyridinium (ASP+) HEK293-OCT3 Chen, 2022
SLC22A3 OCT3 Amiloride 3 Metformin HEK293-OCT3 Chen, 2022

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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