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3,4-methylenedioxymetamphetamine (MDMA)

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

No substrate information.


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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
SLC22A1 OCT1 3,4-methylenedioxymetamphetamine (MDMA) 24.2 N-methylpyridinium HEK293-OCT1 Amphoux, 2006
SLC22A2 OCT2 3,4-methylenedioxymetamphetamine (MDMA) 1.63 N-methylpyridinium HEK293-OCT2 Amphoux, 2006
SLC22A3 OCT3 3,4-methylenedioxymetamphetamine (MDMA) 73.6 N-methylpyridinium HEK293-OCT3 Amphoux, 2006
rat_Slc22a1 Oct1, Orct1, Roct1 3,4-methylenedioxymetamphetamine (MDMA) 0.82 N-methylpyridinium HEK293-rOCT1 Amphoux, 2006
rat_Slc22a2 OCT2, OCT2r, rOCT2 3,4-methylenedioxymetamphetamine (MDMA) 2.77 N-methylpyridinium HEK293-rOCT2 Amphoux, 2006
rat_Slc22a3 Oct3 3,4-methylenedioxymetamphetamine (MDMA) 1.6 N-methylpyridinium HEK293-rOCT3 Amphoux, 2006

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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