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17beta-estradiol

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

No substrate information.


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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
SLC22A1 OCT1 17beta-estradiol 5.73 1-methyl-4-phenylpyridinium (MPP+) HEK293-OCT1 Hayer-Zillgen, 2002
SLCO1B1 OATP1B1, OATP-C, OATP2, LST-1 17beta-estradiol 3.9 Estradiol-17beta-glucuronide CHO-OATP1B1 Gui, 2008
SLCO1B3 OATP1B3, OATP8 17beta-estradiol 12.9 Estradiol-17beta-glucuronide CHO-OATP1B3 Gui, 2008
SLCO1B1 OATP1B1, OATP-C, OATP2, LST-1 17beta-estradiol 3.3 Estradiol-17beta-glucuronide CHO-OATP1B1 Gui, 2009
ABCG2 BCRP, MXR 17beta-estradiol 4.8 Not applicable Steroid Sensitivity of K562-BCRP Imai, 2002

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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