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(-)-3-(3,4-dihydroxyphenyl)-2-methyl-l-alanine sesquihydrate

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

No substrate information.


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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
ABCC2 MRP2, cMOAT (-)-3-(3,4-dihydroxyphenyl)-2-methyl-l-alanine sesquihydrate 64.2 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC3 MRP3 (-)-3-(3,4-dihydroxyphenyl)-2-methyl-l-alanine sesquihydrate 41.2 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC4 MRP4 (-)-3-(3,4-dihydroxyphenyl)-2-methyl-l-alanine sesquihydrate 8.08 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCB11 BSEP (-)-3-(3,4-dihydroxyphenyl)-2-methyl-l-alanine sesquihydrate >133 Taurocholate Sf9 cell membrane vesicles Morgan, 2013

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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