Important Transporter Localization in the Intestinal Epithelia
------------------------------
| |
| <--- OCT2
| |
| <--- OCT3
| |
| <--- OCTN1 --->
OCT1 ---> |
| <--- OCTN2 --->
| |
| <--- OATP1A2
<--- MRP1 |
| <--- OATP2B1
Blood | | Intestine
| MRP2 --->
<--- MRP3 |
| MDR1 --->
| |
| BCRP --->
OSTalpha |
<------------> <--- PEPT1
OSTbeta |
| <--- ASBT
| |
| <--- MCT1
| |
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Basolateral Apical
arrows denote primary direction of transport
MCT1 is shown, but not currently contained in our database
The image shows a simplified cell outline with marked basolateral and apical sides. OCT1 is placed as an influx transporter on the basolateral side, while MRP1 and MRP3 are basolateral efflux transporters. The OSTalpha-OSTbeta complex is a bi-directional transporter on the basolateral membrane. OCT3, OATP1A2, OATP2B1, PEPT1, ASBT, and MCT1 are all apical influx transporters, with MCT1 also being marked as a transporter that is shown in the image but not in the database. MRP2, MDR1, and BCRP are apical efflux transporters, while OCTN1 and OCTN2 are bi-directional apical membrane transporters.