Important Transporter Localization in the Kidney
Blood Urine
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| |
| <--- OCTN1 --->
| |
OCT2 ---> <--- OCTN2 --->
| |
OCT3 ---> <--- OAT4
| |
OAT1 ---> <--- OATP1A2
| |
OAT2 ---> MATE1 --->
| |
OAT3 ---> MATE2K --->
| |
<--- MRP1 MRP2 --->
| Renal |
<--- MRP3 cell MRP4 --->
| |
<--- MRP5 MDR1 --->
| |
<--- MRP6 BCRP --->
| |
OSTalpha <--- PEPT1
<------------> |
OSTbeta <--- PEPT2
| |
OATP4C1 ---> <--- ASBT
| |
| <--- URAT1
| |
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Basolateral Apical
arrows denote primary direction of transport
OATP4C1 is shown, but not currently contained in our database
The image shows a simplified cell outline with marked basolateral side facing the blood and the apical side facing urine. OCT2, OCT3, OAT1, OAT2, and OAT3 are placed as influx transporters on the basolateral side. OATP4C1 is also marked as an influx transporter in the image but not in the database. MRP1, MRP3, MRP5, and MRP6 are placed as efflux transporters on the basolateral side, while OSTalpha-OSTbeta complex is a basolateral bi-directional transporter. OAT4, OATP2B1, PEPT1, PEPT2, ASBT, and URAT1 are marked as influx transporters on the apical side. MATE1, MATE2K, MRP2, MRP4, and MDR1 are apical efflux transporters, while OCTN1 and OCTN2 are bi-directional apical membrane transporters.