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Liver

Localization Information
qPCR Expression Data (Pooled)
RNA-Seq Expression Data
qPCR Expression Data (Individual)

Localization Information

Important Transporter Localization in the Liver

text version of image
image associated links:
surface genes: OCT1, OCT3, OSTalpha, OSTbeta, MRP3, MRP4, MRP6, NTCP, OCTN2, OAT2, OATP1B1, OATP1B3, OATP2B1
bile canaliculus genes: MDR1, MDR3, BCRP, MATE1, BSEP, MRP2

Notes:

The arrows indicate the transporter's primary direction of transport. However, for some SLC transporters, transport in the opposite direction is also possible. For example, estrone sulfate efflux is trans-stimulated by extracellular taurocholate in OATP1B1-expressing oocytes (Mahagita et al., Am J Physiol Gastrointest Liver Physiol. 2007 Jul;293(1):G271-8).
The orange transporter OAT7 is shown, but not currently contained in our database.
While not shown here, OATP1A2 is in cholangiocytes.

Expression Data

Liver - qPCR (Pooled)

Asterisk and bold rows indicates important transporters in the organ as identified in the organ diagram

Transporter	Synonyms	Relative Expression (Transporter mRNA/PPIA mRNA)
ABCB1*	MDR1, P-gp	`0.0230`
ABCB4*	MDR3	`0.150`
ABCB11*	BSEP	`0.163`
ABCC1*	MRP1	`0.00330`
ABCC2*	MRP2, cMOAT	`0.208`
ABCC3*	MRP3	`0.114`
ABCC4*	MRP4	`0.00294`
ABCC5	MRP5	`0.00500`
ABCC6*	MRP6	`0.00982`
ABCG2*	BCRP, MXR	`0.0139`
SLC10A1*	NTCP	`0.486`
SLC10A2	ASBT, SBAT2	BLQ
SLC15A1	PEPT1	`0.0522`
SLC15A2	PEPT2	`0.000631`
SLC22A1*	OCT1	`2.230`
SLC22A2	OCT2	`0.0000367`
SLC22A3*	OCT3	`0.124`
SLC22A4	OCTN1	`0.000202`
SLC22A5*	OCTN2	`0.00248`
SLC22A6	OAT1	`0.0000606`
SLC22A7*	OAT2	`0.818`
SLC22A8	OAT3	`0.000135`
SLC22A11	OAT4	BLQ
SLC22A12	URAT1	BLQ
SLCO1A2*	OATP1A2, OATP-A	`0.00324`
SLCO1B1*	OATP1B1, OATP-C, OATP2, LST-1	`0.252`
SLCO2B1*	OATP2B1, OATP-B	`0.0677`

(n=14): male & female, 18-59-yr, Caucasian
BLQ = below limit of quantitation
Bold rows indicate important transporters in the organ as identified in the organ diagram

Graphical Representation of qPCR Data (Pooled)

Data from Nishimura M, Naito S
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Liver - RNA seq

Asterisk and bold rows indicates important transporters in the organ as identified in the organ diagram

Transporter	Synonyms	Donor 1	Donor 2	Donor 3	Average of All Donors	SD of All Donors
Transporter	Synonyms	Relative Expression (RPKM)			Average of All Donors	SD of All Donors
ABCB1*	MDR1, P-gp	BLQ	`0.766`	BLQ	`0.256`	`0.443`
ABCB4*	MDR3	`4.407`	`7.726`	`3.050`	`5.061`	`2.405`
ABCB11*	BSEP	`20.866`	`30.316`	`26.814`	`25.999`	`4.777`
ABCC1*	MRP1	`1.023`	`0.904`	`0.507`	`0.811`	`0.270`
ABCC2*	MRP2, cMOAT	`5.219`	`13.690`	`1.535`	`6.815`	`6.233`
ABCC3*	MRP3	`24.679`	`22.028`	`37.581`	`28.096`	`8.321`
ABCC4*	MRP4	`0.530`	`0.0889`	BLQ	`0.206`	`0.284`
ABCC5	MRP5	BLQ	BLQ	BLQ	BLQ	BLQ
ABCC6*	MRP6	`61.085`	`73.116`	`65.858`	`66.686`	`6.058`
ABCG2*	BCRP, MXR	`0.559`	`4.106`	BLQ	`1.555`	`2.227`
OSTalpha*	OSTA	`11.717`	`40.059`	`19.047`	`23.608`	`14.711`
OSTbeta*	OSTB	BLQ	BLQ	BLQ	BLQ	BLQ
SLC10A1*	NTCP	`61.171`	`171.654`	`96.865`	`109.897`	`56.383`
SLC10A2	ASBT, SBAT2	BLQ	BLQ	BLQ	BLQ	BLQ
SLC15A1	PEPT1	`2.314`	`0.971`	BLQ	`1.095`	`1.162`
SLC15A2	PEPT2	`0.656`	BLQ	`1.029`	`0.562`	`0.521`
SLC22A1*	OCT1	`312.661`	`348.980`	`304.858`	`322.166`	`23.547`
SLC22A2	OCT2	BLQ	`1.017`	BLQ	`0.339`	`0.587`
SLC22A3*	OCT3	`5.669`	`7.808`	`5.698`	`6.392`	`1.227`
SLC22A4	OCTN1	BLQ	`0.476`	BLQ	`0.159`	`0.275`
SLC22A5*	OCTN2	`2.678`	`2.007`	BLQ	`1.562`	`1.394`
SLC22A6	OAT1	`0.173`	BLQ	BLQ	`0.0578`	`0.100`
SLC22A7*	OAT2	`83.729`	`158.266`	`143.275`	`128.423`	`39.426`
SLC22A8	OAT3	BLQ	BLQ	BLQ	BLQ	BLQ
SLC22A11	OAT4	BLQ	BLQ	BLQ	BLQ	BLQ
SLC22A12	URAT1	`1.007`	BLQ	BLQ	`0.336`	`0.581`
SLC47A1*	MATE1	`14.563`	`25.880`	`13.852`	`18.098`	`6.749`
SLC47A2	MATE2K	BLQ	`0.231`	`0.648`	`0.293`	`0.329`
SLCO1A2*	OATP1A2, OATP-A	`0.383`	`1.448`	BLQ	`0.610`	`0.750`
SLCO1B1*	OATP1B1, OATP-C, OATP2, LST-1	`21.847`	`31.065`	`5.770`	`19.561`	`12.802`
SLCO1B3*	OATP1B3, OATP8	`6.265`	`17.929`	`1.340`	`8.511`	`8.520`
SLCO2B1*	OATP2B1, OATP-B	`64.395`	`71.588`	`61.619`	`65.867`	`5.145`

Click here for information on samples
BLQ = below limit of quantitation

Graphical Representation of RNA Seq Data

Data from Pharmacogenetics of Membrane Transporters Project

Liver - qPCR (Individual)

Asterisk and bold rows indicates important transporters in the organ as identified in the organ diagram

Transporter	Synonyms	2^(-ΔΔC_t)
Transporter	Synonyms	First Quartile	Median	Third Quartile
ABCB1*	MDR1, P-gp	`477.522`	`694.320`	`1086.297`
ABCB4*	MDR3	`257.638`	`546.753`	`891.088`
ABCB11*	BSEP	`352.341`	`616.243`	`1018.038`
ABCC1*	MRP1	`20.733`	`33.483`	`44.412`
ABCC2*	MRP2, cMOAT	`938.747`	`1442.907`	`2002.345`
ABCC3*	MRP3	`267.612`	`412.143`	`559.016`
ABCC4*	MRP4	`20.036`	`31.198`	`45.355`
ABCC5	MRP5	`44.412`	`79.936`	`126.251`
ABCC6*	MRP6	`165.789`	`272.812`	`397.277`
ABCG2*	BCRP, MXR	`18.411`	`24.748`	`43.087`
SLC10A1*	NTCP	`211.626`	`1190.238`	`3010.731`
SLC10A2	ASBT, SBAT2	`233.208`	`1119.859`	`3452.739`
SLC15A1	PEPT1	`162.137`	`270.212`	`477.522`
SLC15A2	PEPT2	`42.426`	`88.337`	`155.867`
SLC22A1*	OCT1	`1057.213`	`2843.611`	`7081.041`
SLC22A2	OCT2	`12.229`	`480.685`	`767.758`
SLC22A3*	OCT3	`694.320`	`891.088`	`1190.238`
SLC22A4	OCTN1	`11.073`	`22.163`	`689.569`
SLC22A5*	OCTN2	`103.410`	`128.846`	`158.794`
SLC22A6	OAT1	`45.393`	`131.028`	`282.678`
SLC22A7*	OAT2	`20.435`	`41.261`	`67.198`
SLC22A8	OAT3	`18.717`	`54.696`	`88.337`
SLC22A11	OAT4	`4.611`	`12.152`	`74.728`
SLC22A12	URAT1	`1.903`	`6.576`	`6.720`
SLC47A1*	MATE1	`397.277`	`559.016`	`841.991`
SLC47A2	MATE2K	`15.602`	`42.682`	`181.075`
SLCO1A2*	OATP1A2, OATP-A	`18.717`	`53.161`	`172.819`
SLCO1B1*	OATP1B1, OATP-C, OATP2, LST-1	`2309.893`	`4054.872`	`6258.392`
SLCO1B3*	OATP1B3, OATP8	`1545.761`	`2475.672`	`4410.248`
SLCO2B1*	OATP2B1, OATP-B	`1390.142`	`2105.750`	`3187.786`

(n=59): male & female, Caucasian
Quantitative RT-PCR was performed on RNA obtained from the renal cortex of human donors using a
custom SYBR green open array (Life Technologies, Grand Island, NY). Datapoints with the maximum
raw C_t values were removed. Data are normalized to the mean of three housekeeping genes and is
presented as 2^-ΔΔC_t (horizontal line is the median value) after normalizing to the lowest expressed
sample of the tissue.

Graphical Representation of qPCR Data (n=59)

Data from Pharmacogenetics of Membrane Transporters Project

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