UCSF home page | About UCSF | UCSF Medical Center

Skip to TransPortal content

Enlarge Text
Click to increase the text size. Restore Text
Click to restore original text size. Reduce Text
Click to decrease the text size.


Decrease the text size \| Restore text size \| Increase the text size

Kidney

Localization Information
qPCR Expression Data (Pooled)
RNA-Seq Expression Data
qPCR Expression Data (Individual)

Localization Information

Important Transporter Localization in the Kidney

text version of image
image associated links:
basolateral genes: OCT2, OCT3, OAT1, OAT2, OAT3, MRP1, MRP3, MRP5, MRP6, OSTalpha, OSTbeta
apical genes: OCTN1, OCTN2, OAT4, OATP1A2, MATE1, MATE2K, MRP2, MRP4, MDR1, BCRP, PEPT1, PEPT2, ASBT, URAT1

Notes:

The distribution of transporters can vary across the length of the nephron. For example, PEPT1 and PEPT2 are only expressed in the proximal tubule, but both are absent from the distal tubule.
The arrows indicate the transporter's primary direction of transport. However, for some SLC transporters, transport in the opposite direction is also possible. For example, para-aminohippurate efflux is trans-stimulated by extracellular para-aminohippurate or glutarate in OAT1-expressing oocytes (Apiwattanakul et al., Mol Pharmacol. 1999 May;55(5):847-54).
The orange transporter OATP4C1 is shown, but not currently contained in our database.

Expression Data

Kidney - qPCR (Pooled)

Asterisk and bold rows indicates important transporters in the organ as identified in the organ diagram

Transporter	Synonyms	Relative Expression (Transporter mRNA/PPIA mRNA)
ABCB1*	MDR1, P-gp	`0.0851`
ABCB4	MDR3	`0.000425`
ABCB11	BSEP	BLQ
ABCC1*	MRP1	`0.0141`
ABCC2*	MRP2, cMOAT	`0.0751`
ABCC3*	MRP3	`0.0484`
ABCC4*	MRP4	`0.180`
ABCC5*	MRP5	`0.0193`
ABCC6*	MRP6	`0.00873`
ABCG2*	BCRP, MXR	`0.00463`
SLC10A1	NTCP	`0.00185`
SLC10A2*	ASBT, SBAT2	`0.0565`
SLC15A1*	PEPT1	`0.0292`
SLC15A2*	PEPT2	`0.0297`
SLC22A1	OCT1	`0.00389`
SLC22A2*	OCT2	`0.139`
SLC22A3*	OCT3	`0.0499`
SLC22A4*	OCTN1	`0.0274`
SLC22A5*	OCTN2	`0.0511`
SLC22A6*	OAT1	`0.853`
SLC22A7*	OAT2	`0.471`
SLC22A8*	OAT3	`0.818`
SLC22A11*	OAT4	`0.125`
SLC22A12*	URAT1	`0.976`
SLCO1A2*	OATP1A2, OATP-A	`0.00199`
SLCO1B1	OATP1B1, OATP-C, OATP2, LST-1	BLQ
SLCO2B1	OATP2B1, OATP-B	`0.0262`

(n=14): male & female, 18-59-yr, Caucasian
BLQ = below limit of quantitation

Graphical Representation of qPCR Data (Pooled)

Data from Nishimura M, Naito S
Back to top

Kidney - RNA seq

Asterisk and bold rows indicates important transporters in the organ as identified in the organ diagram

Transporter	Synonyms	Donor 1	Donor 2	Donor 3	Donor 4	Average of All Donors	SD of All Donors
Transporter	Synonyms	Relative Expression (RPKM)				Average of All Donors	SD of All Donors
ABCB1*	MDR1, P-gp	`1.005`	`0.880`	BLQ	BLQ	`0.471`	`0.547`
ABCB4	MDR3	BLQ	BLQ	BLQ	BLQ	BLQ	BLQ
ABCB11	BSEP	BLQ	BLQ	`0.274`	`0.591`	`0.216`	`0.281`
ABCC1*	MRP1	`6.044`	`6.776`	`8.277`	`9.124`	`7.555`	`1.399`
ABCC2*	MRP2, cMOAT	`0.718`	`0.632`	BLQ	BLQ	`0.337`	`0.391`
ABCC3*	MRP3	`6.478`	`8.140`	`2.360`	`8.187`	`6.291`	`2.739`
ABCC4*	MRP4	`2.683`	`4.104`	`3.259`	`2.343`	`3.097`	`0.770`
ABCC5*	MRP5	`5.409`	`9.912`	`9.795`	`16.597`	`10.428`	`4.616`
ABCC6*	MRP6	`20.119`	`9.088`	`5.064`	`5.461`	`9.933`	`7.028`
ABCG2*	BCRP, MXR	`0.846`	`0.880`	`0.716`	`0.515`	`0.739`	`0.165`
OSTalpha*	OSTA	`0.938`	`0.825`	BLQ	`1.570`	`0.833`	`0.645`
OSTbeta*	OSTB	`3.753`	`3.301`	`2.330`	BLQ	`2.346`	`1.673`
SLC10A1	NTCP	BLQ	`0.188`	BLQ	BLQ	`0.0470`	`0.0940`
SLC10A2*	ASBT, SBAT2	`1.173`	`0.952`	BLQ	BLQ	`0.531`	`0.620`
SLC15A1*	PEPT1	BLQ	`0.560`	`0.989`	BLQ	`0.387`	`0.480`
SLC15A2*	PEPT2	`5.177`	`5.190`	`2.056`	`6.046`	`4.617`	`1.755`
SLC22A1	OCT1	`0.381`	`1.845`	BLQ	`1.277`	`0.876`	`0.839`
SLC22A2*	OCT2	`32.008`	`65.990`	`61.588`	`17.858`	`44.361`	`23.235`
SLC22A3*	OCT3	`2.545`	`2.771`	`0.376`	`3.042`	`2.184`	`1.222`
SLC22A4*	OCTN1	`0.780`	`1.235`	`2.905`	`1.566`	`1.621`	`0.914`
SLC22A5*	OCTN2	`11.056`	`13.894`	`12.749`	`7.402`	`11.276`	`2.833`
SLC22A6*	OAT1	`95.776`	`47.663`	`3.258`	`6.387`	`38.271`	`43.350`
SLC22A7*	OAT2	`38.458`	`14.552`	`3.001`	BLQ	`14.003`	`17.469`
SLC22A8*	OAT3	`39.385`	`31.198`	BLQ	`1.312`	`17.974`	`20.281`
SLC22A11*	OAT4	`30.808`	`14.369`	`2.889`	`2.769`	`12.708`	`13.236`
SLC22A12*	URAT1	`64.548`	`31.924`	`3.010`	`0.927`	`25.102`	`29.861`
SLC47A1*	MATE1	`18.930`	`17.703`	`2.912`	`3.425`	`10.743`	`8.762`
SLC47A2*	MATE2K	`9.857`	`7.870`	`1.883`	`0.508`	`5.030`	`4.536`
SLCO1A2*	OATP1A2, OATP-A	BLQ	BLQ	BLQ	BLQ	BLQ	BLQ
SLCO1B1	OATP1B1, OATP-C, OATP2, LST-1	BLQ	`0.324`	BLQ	BLQ	`0.0809`	`0.162`
SLCO1B3	OATP1B3, OATP8	BLQ	`0.276`	BLQ	BLQ	`0.0689`	`0.138`
SLCO2B1	OATP2B1, OATP-B	`6.842`	`9.309`	`3.115`	`6.719`	`6.496`	`2.550`

Click here for information on samples
Donor #4 is a child donor (4 yr. old)
BLQ = below limit of quantitation
Samples are from the renal cortex and are not representative of all parts of the kidney or the nephrons

Graphical Representation of RNA Seq Data

Data from Pharmacogenetics of Membrane Transporters Project

Kidney - qPCR (Individual)

Asterisk and bold rows indicates important transporters in the organ as identified in the organ diagram

Transporter	Synonyms	2^(-ΔΔC_t)
Transporter	Synonyms	First Quartile	Median	Third Quartile
ABCB1*	MDR1, P-gp	`547.184`	`695.802`	`986.289`
ABCB4	MDR3	`8.418`	`16.125`	`24.261`
ABCB11	BSEP	`8.491`	`21.544`	`40.138`
ABCC1*	MRP1	`78.001`	`113.025`	`177.563`
ABCC2*	MRP2, cMOAT	`83.146`	`186.360`	`290.686`
ABCC3*	MRP3	`18.376`	`29.636`	`58.064`
ABCC4*	MRP4	`212.151`	`299.418`	`379.091`
ABCC5*	MRP5	`276.928`	`373.031`	`572.084`
ABCC6*	MRP6	`47.391`	`67.438`	`115.882`
ABCG2*	BCRP, MXR	`35.728`	`49.323`	`66.919`
SLC10A1	NTCP	`20.704`	`30.572`	`57.331`
SLC10A2*	ASBT, SBAT2	`19.808`	`62.961`	`222.964`
SLC15A1*	PEPT1	`62.908`	`91.635`	`160.147`
SLC15A2*	PEPT2	`4.793`	`10.602`	`20.464`
SLC22A1	OCT1	`16.278`	`26.847`	`40.746`
SLC22A2*	OCT2	`946.680`	`1496.801`	`1811.037`
SLC22A3*	OCT3	`117.122`	`168.394`	`230.534`
SLC22A4*	OCTN1	`7.186`	`11.950`	`22.624`
SLC22A5*	OCTN2	`472.706`	`613.555`	`771.577`
SLC22A6*	OAT1	`502.228`	`1415.602`	`3047.126`
SLC22A7*	OAT2	`13.514`	`21.330`	`32.233`
SLC22A8*	OAT3	`91.635`	`429.863`	`1913.812`
SLC22A11*	OAT4	`74.559`	`230.327`	`482.249`
SLC22A12*	URAT1	`85.145`	`288.663`	`482.249`
SLC47A1*	MATE1	`125.082`	`379.091`	`713.820`
SLC47A2*	MATE2K	`29.636`	`55.812`	`93.851`
SLCO1A2*	OATP1A2, OATP-A	`25.530`	`52.859`	`160.147`
SLCO1B1	OATP1B1, OATP-C, OATP2, LST-1	`21.618`	`47.149`	`165.411`
SLCO1B3	OATP1B3, OATP8	`29.636`	`121.957`	`308.833`
SLCO2B1	OATP2B1, OATP-B	`202.798`	`342.110`	`463.953`

(n=57): male & female, Caucasian
Quantitative RT-PCR was performed on RNA obtained from the renal cortex of human donors using a
custom SYBR green open array (Life Technologies, Grand Island, NY). Datapoints with the maximum
raw C_t values were removed. Data are normalized to the mean of three housekeeping genes and is
presented as 2^-ΔΔC_t (horizontal line is the median value) after normalizing to the lowest expressed
sample of the tissue.
Samples are from the renal cortex and are not representative of all parts of the kidney or the nephrons

Graphical Representation of qPCR Data (n=57)

Data from Pharmacogenetics of Membrane Transporters Project

Back to top

Contact us | Glossary